Meindert Danhof, PharmD, PhD
Meindert Danhof, PharmD, PhD
CurrentPresident of the European Federation of Pharmaceutical Sciences (EUFEPS)

Meindert Danhof studied Pharmacy at Groningen University and received his Pharm D in 1976. His PhD was obtained from Leiden University in 1980 under the direction of Professor D.D. Breimer. From 1980-1983, he was a post-doctoral research fellow with Professor G. Levy, in the Department of Pharmaceutics, State University of New York at Buffalo, USA. Subsequently he received further specialist training in clinical pharmacology as a visiting scientist at Stanford University Medical center between 1983-1986.

Meindert Danhof’s research interest is in the development of new theoretical concepts in pharmacokinetic-pharmacodynamic [PKPD] modeling. In recent years, important contributions in his research have been on the incorporation of i] receptor theory and ii] dynamical systems analysis. This has resulted in a new class of ‘mechanism-based’ PKPD models with considerably improved properties for extrapolation and prediction. Subsequent research has focused on the development of novel concepts of ‘disease system analysis’, while at present his research is directed to ‘Systems Pharmacology’ as a novel approach to the analysis of the interaction between drug action and disease progression.

Meindert Danhof has an active interest in the dissemination of PKPD and systems pharmacology modeling concepts through the organization of international conferences, workshops and courses. He is the Founder and Chairman of the series of international conferences ‘Measurement and Kinetics of In Vivo Drug Effects’ in Noordwijkerhout, the Netherlands in 1990, 1994, 1998, 2002, 2006, 2010 and 2014.

In 1998, he has established LAP&P Consultants BV, which provides a professional infrastructure for consultancy services in the area of advanced PKPD modeling to the pharmaceutical industry, including actual data-analysis and clinical trial simulation. In 2007, he was the founder of the ‘TIPharma mechanism-based PKPD modeling platform’, which aims at the development of a mechanism-based PKPD model library and database for application in drug discovery and development.

Meindert Danhof has been an AAPS Fellow since 1998. In 1993, he received the Organon Research Prize for his contributions to research on PKPD relationships and in 1997 the ‘FIP Pharmaceutical Scientist of the Year Award’ at the 57th World Congress of Pharmacy and Pharmaceutical Sciences in Vancouver, Canada. In 2004, he received the Rawls Palmer Award at the 105th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) in Miami, USA, and in 2006 the ‘New Safe Medicines Faster Award’ of the European Federation of Pharmaceutical Sciences (EUFEPS). Most recent awards include the Ditinguished Scientist Award of the American College of Clinical Pharmacology (ACCP) in 2009 and the Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism of the American Association of Pharmaceutical Sciences (AAPS) in 2010.

Meindert Danhof is President of the European Federation of Pharmaceutical Sciences (EUFEPS) and is listed in the ISI-list of Highly Cited Researchers.