Leslie Z. Benet, PhD, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, CA 94143-0912, USA

Influence and stature of a scientific discipline comes about when that discipline offers a needed service or intellectual advancement that is not found within other disciplines. The Pharmacy profession, Pharmacy education and Pharmaceutical Sciences over the years have searched for the key component that would make our discipline/profession not only unique, but derive influence and stature. We have advanced along many avenues during our search: compounding, manufacturing, medicinal chemistry, pharmacognosy and natural product chemistry, physical pharmacy, drug delivery, clinical and patient oriented pharmacy practice, clinical pharmacology, pharmacoeconomics, pharmacoepidemiology, nanotechnology, drug metabolism/transport and personalized medicine. I will touch briefly on each of these Pharmacy/Pharmaceutical Sciences subdisciplines in terms of the educational driving force that they generate, their influence on the profession and health care and their contribution to the stature of our profession. However, I will concentrate on what I believe to be an advancement that occurred through Pharmacy education, almost exclusively, which has had the largest impact. That advancement is the invention and development of clearance concepts. In my mind, as I will try to convince you during my talk, clearance is the vehicle that provided the sound basis for our disciplines’ unique rolls in clinical and patient oriented practice, drug metabolism/transport and personalized medicine. It is a parameter that medicinal chemists and drug delivery scientists take into consideration in their new advances in drug development and it is the basis for the pharmacist, in essence, assuming the roll of clinical pharmacology in patient care.